Newborn calves are immunodeficient. Colostrum provides them immunity, but it also can be a potential source of pathogen microorganism such as Mycobacterium avium ssp. paratuberculosis (Johne’s disease), Mycoplasma spp., Escherichia coli, and Salmonella spp. For this reason, heat treating colostrum to reduce or eliminate pathogens is a common practice in the dairy industry. However, heat treatment may affect colostrum immunoglobulin G concentration.