Salmonella enterica serotype Dublin is an important cause of illness among dairy calves younger than 2 months of age. Infection with S. Dublin can occur when susceptible calves ingest the bacteria in milk or manure from infected animals. In addition to diarrhea, the most common manifestation of S. Dublin in calves is pneumonia.
As a host-adapted strain, infected animals may become lifetime carriers of the infection and shed S. Dublin in feces, milk, and colostrum. It is a difficult infection to treat because this pathogen is frequently antibiotic-resistant. Therefore, stimulating host immunity against S. Dublin through vaccination may be a viable strategy to control this disease.